LONGITUDINAL FLUCTUATIONS IN PD1 AND PD-L1 EXPRESSION IN ASSOCIATION WITH CHANGES IN ANTI-VIRAL IMMUNE RESPONSE IN CHRONIC HEPATITIS B

Longitudinal fluctuations in PD1 and PD-L1 expression in association with changes in anti-viral immune response in chronic hepatitis B

Abstract Background Controversy exists regarding the role of PD1 and its ligand PD-L1 in chronic hepatitis B infection.In some studies, persistent HBV infection has been attributed to high levels of PD-1 and PD-L1 expression on HBV-specific T-cells and antigen-presenting Spacecraft Model Kit cells (APCs) respectively.Other studies revealed that the

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Generation, analysis and functional annotation of expressed sequence tags from the ectoparasitic mite Psoroptes ovis

Abstract Background Sheep scab is caused by Psoroptes ovis and is arguably the most important ectoparasitic disease affecting sheep in the UK.The disease is highly contagious and causes and considerable pruritis and irritation and is therefore a major welfare concern.Current methods of treatment are unsustainable and in order to elucidate novel met

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Recrystallization of Cu-30Zn brass during friction stir welding

The recrystallization process of Cu-30Zn brass during friction stir welding (FSW) was investigated.The microstructural evolution in the stirring period and the subsequent normal air-cooling period were separately studied by using stop-action technology, liquid nitrogen cooling, and subsequent heat treatment.During the stirring period, the initial l

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Keyword-Enhanced Multi-Expert Framework for Hate Speech Detection

The proliferation of hate speech on the Internet is harmful to the psychological health of individuals and society.Thus, establishing and supporting the development of hate speech detection and deploying evasion techniques is a vital task.However, existing hate speech detection methods tend to ignore the sentiment features of target sentences and h

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Diagnostic accuracy of a three-protein signature in women with suspicious breast lesions: a multicenter prospective trial

Abstract Background Mammography screening has been proven to detect breast cancer at an early stage and reduce mortality; however, it has low accuracy in young women or women with dense breasts.Blood-based diagnostic tools may overcome the limitations of mammography.This study assessed the diagnostic performance of a three-protein signature in pati

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